The Association Between Multiple Myeloma and Neuropsychiatric Manifestations: A Narrative Review

The association between MM and neuropsychiatric manifestations is likely multifactorial. This review underscores the critical need for integrated mental health support within MM management and calls for further research into possible causes such as pathophysiological inflammation, paraneoplastic phenomena related to monoclonal proteins, and prolonged exposure to steroid therapy. Routine neuropsychiatric screening and assessment are imperative for timely identification and intervention to improve overall prognosis in MM patients.

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Publication Details

Journal
Psycho-Oncology
Published
2026-03-26
DOI
https://doi.org/10.1002/pon.70438
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

The Association Between Multiple Myeloma and Neuropsychiatric Manifestations: A Narrative Review

Laurel Spaccarelli, Joanna Kowalik, Srinagesh Mannekote Thippaiah, M F Block et al.
Psycho-Oncology
Multiple Myeloma Research and Treatments
article

The Association Between Multiple Myeloma and Neuropsychiatric Manifestations: A Narrative Review

Laurel Spaccarelli, Joanna Kowalik, Srinagesh Mannekote Thippaiah, M F Block, Catherine S. Taghizadeh, Natalie Ertz‐Archambault
article en

Abstract

The association between MM and neuropsychiatric manifestations is likely multifactorial. This review underscores the critical need for integrated mental health support within MM management and calls for further research into possible causes such as pathophysiological inflammation, paraneoplastic phenomena related to monoclonal proteins, and prolonged exposure to steroid therapy. Routine neuropsychiatric screening and assessment are imperative for timely identification and intervention to improve overall prognosis in MM patients.

Psycho-OncologyVol. 35(4)
Creighton University (US), Valley Medical Center (US), Healthwise (US)
Good health and well-being
Openalex Percentile: Top 4%
Multiple Myeloma Research and Treatments
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