Impact of a Cellular Host-Response Sepsis Diagnostic on Clinical Decision Making in the Emergency Department: A Vignette-Based Study
Objectives: Sepsis is a complex pathogen-host interaction that traditional laboratories do not easily detect.A test that rapidly assesses immune dysregulation could improve early diagnosis and clinical decision making.This study evaluates ease of application of a new host-response sepsis diagnostic test (IntelliSep; Cytovale, Inc) and its ability to affect decision making, risk stratification, and diagnostic efficacy in the emergency department (ED).Methods: This was a case vignette-based, randomized, multisite decision-impact study.We conducted the study with ED clinicians from 3 health care institutions,
Authors
- Matthew Chinn (ORCID: https://orcid.org/0000-0002-2127-3505)
- Nathan A. Ledeboer
- Howard A Smithline (ORCID: https://orcid.org/0000-0001-6972-5833)
- Donna M. Wolk (ORCID: https://orcid.org/0000-0003-2828-5135)
- Hollis R. O’Neal (ORCID: https://orcid.org/0000-0001-8854-6822)
- Eric Melnychuk (ORCID: https://orcid.org/0000-0003-1466-6834)
- Chadd K. Kraus (ORCID: https://orcid.org/0000-0003-3628-2073)
- Tom P. Aufderheide
- Roya Sheybani
- Christopher Pfaff
- Robert Scoggins
- Thomas Carver
- Christopher B. Thomas
Institutions
- Geisinger Medical Center (US)
- Our Lady of the Lake Regional Medical Center (US)
- Lehigh Valley Hospital-Pocono (US)
- Baystate Medical Center (US)
- Medical College of Wisconsin (US)
- Lehigh Valley Health Network (US)
- Cytovale (United States) (US)
- Baystate Health (US)
- Kootenai Medical Center (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Franciscan Missionaries of Our Lady University (US)
Publication Details
- Journal
- Journal of the American College of Emergency Physicians Open
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1016/j.acepjo.2026.100358
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00