Isolation and characterization of blastmycetin G, a sofa-conformation fixed analog of teleocidin B’s, produced by <i>Streptomyces blastmyceticus</i>
Blastmycetin G (1), a 5-hydroxy derivative of teleocidin B's, was isolated from Streptomyces blastmyceticus NA34-17. The 5-hydroxy group fixes exclusively the nine-membered lactam ring into a sofa (trans-amide) conformation. The significantly weaker binding affinity for PKCα and PKCδ-C1 domains (400-800 times less than teleocidin B-4) supports that the sofa conformer is biologically inactive.
Authors
- Chihiro Tsukano (ORCID: https://orcid.org/0000-0002-9361-0857)
- Kazuhiro Irie (ORCID: https://orcid.org/0000-0001-7109-8568)
- Ryo C. Yanagita (ORCID: https://orcid.org/0000-0002-9217-5507)
- Shin-ichiro Kajiyama
Institutions
- Doshisha University (JP)
- Kagawa University (JP)
- Kyoto University (JP)
- Kindai University (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1093/bbb/zbag044
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00