Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries
We have shown that circulating CD8<sup>+</sup> T cells provide a potential biomarker to distinguish ChILI from DILI and AIH, and highlight different mechanistic pathways between ChILI and other immune-mediated liver injuries.
Authors
- Ye Htun Oo (ORCID: https://orcid.org/0000-0002-0495-6734)
- Amber Bozward (ORCID: https://orcid.org/0000-0001-6637-8952)
- Changhua Ji (ORCID: https://orcid.org/0000-0002-3329-6421)
- Natalia Krajewska
- Hester Franks (ORCID: https://orcid.org/0000-0001-5378-6076)
- Jessie Qian
- Melanie Lingaya (ORCID: https://orcid.org/0000-0002-9390-2315)
- Grace Wootton (ORCID: https://orcid.org/0009-0005-7641-8053)
- Stuart Astbury (ORCID: https://orcid.org/0000-0002-1919-3952)
- Edmond Atallah (ORCID: https://orcid.org/0000-0002-7341-9174)
- Steven W. Kumpf
- Thomas A. Lanz (ORCID: https://orcid.org/0000-0003-2483-3122)
- Mark Sheehan (ORCID: https://orcid.org/0009-0007-4916-796X)
- Ankit Rao (ORCID: https://orcid.org/0000-0003-2403-3264)
- Shashi K. Ramaiah (ORCID: https://orcid.org/0009-0007-9105-9970)
- Mar Riveiro-Barciela
- Scott P. Davies
- Flavia Radulescu
- Lourdes Ruiz-Ortega
- Jane I Grove
- Davor Kresnik
- Guruprasad P Aithal
- Poulam M Patel
Institutions
- Universitat Autònoma de Barcelona (ES)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Pfizer (United States) (US)
- NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
- Vall d'Hebron Hospital Universitari (ES)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- Nottingham Biomedical Research Centre (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1136/jitc-2025-014178
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00