Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries

We have shown that circulating CD8<sup>+</sup> T cells provide a potential biomarker to distinguish ChILI from DILI and AIH, and highlight different mechanistic pathways between ChILI and other immune-mediated liver injuries.

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Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2026-03-01
DOI
https://doi.org/10.1136/jitc-2025-014178
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries

Ye Htun Oo, Amber Bozward, Changhua Ji, Natalia Krajewska et al.
Journal for ImmunoTherapy of Cancer
Cancer Immunotherapy and Biomarkers
article

Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries

Ye Htun Oo, Amber Bozward, Changhua Ji, Natalia Krajewska, Hester Franks, Jessie Qian, Melanie Lingaya, Grace Wootton, Stuart Astbury, Edmond Atallah, Steven W. Kumpf, Thomas A. Lanz, Mark Sheehan, Ankit Rao, Shashi K. Ramaiah, Mar Riveiro-Barciela, Scott P. Davies, Flavia Radulescu, Lourdes Ruiz-Ortega, Jane I Grove, Davor Kresnik, Guruprasad P Aithal, Poulam M Patel
article en

Abstract

We have shown that circulating CD8<sup>+</sup> T cells provide a potential biomarker to distinguish ChILI from DILI and AIH, and highlight different mechanistic pathways between ChILI and other immune-mediated liver injuries.

Journal for ImmunoTherapy of CancerVol. 14(3)
Universitat Autònoma de Barcelona (ES), University Hospitals Birmingham NHS Foundation Trust (GB), Nottingham University Hospitals NHS Trust (GB), University of Nottingham (GB), Pfizer (United States) (US), NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB), Vall d'Hebron Hospital Universitari (ES), NIHR Surgical Reconstruction and Microbiology Research Centre (GB), Nottingham Biomedical Research Centre (GB), NIHR Birmingham Biomedical Research Centre (GB), University of Birmingham (GB)
Good health and well-being
Openalex Percentile: Top 6%
Cancer Immunotherapy and Biomarkers
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