Myeloproliferative Neoplasm With Eosinophilia Exhibiting a Rare GOLGA4-PDGFRB Rearrangement in an Infant: Navigating a Rare Malignancy Amidst Limited Pediatric Guidelines

Myeloid/lymphoid neoplasms with eosinophilia (MLN-eos) are rare hematological malignancies in childhood and limited to isolated case reports in the literature. We discuss the case of an infant who was evaluated for persistent hypereosinophilia and diagnosed with a rare genetic rearrangement; GOLGA4::PDGFRB was previously reported only once in a 13-month-old boy. A literature review of all children with PDGFRB rearrangement was collated in our analysis. The challenges of diagnosis, treatment, and follow-up posed by such a rare genetic disorder with no pediatric guidelines are being discussed.