Reassessment of the Diagnostic Accuracy of HbA <sub>1c</sub> and Glucose for Type 2 Diabetes: A Systematic Review and Meta‐Analysis of Observational Studies

These results suggest that FPG is a more reliable diagnostic marker than HbA<sub>1c</sub> and that uniform global thresholds may not fully reflect population-specific differences. Further high-quality studies are needed to refine diagnostic performance and examine factors influencing accuracy.

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Publication Details

Journal
Diabetes/Metabolism Research and Reviews
Published
2026-03-27
DOI
https://doi.org/10.1002/dmrr.70160
Primary Topic
Diabetes, Cardiovascular Risks, and Lipoproteins
Type
article
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article

Reassessment of the Diagnostic Accuracy of HbA 1c and Glucose for Type 2 Diabetes: A Systematic Review and Meta‐Analysis of Observational Studies

Christina Baechle, Brenda Bongaerts, Sabrina Schlesinger, Ferdinand Valentin Stoye et al.
Diabetes/Metabolism Research and Reviews
Diabetes, Cardiovascular Risks, and Lipoproteins
article

Reassessment of the Diagnostic Accuracy of HbA 1c and Glucose for Type 2 Diabetes: A Systematic Review and Meta‐Analysis of Observational Studies

Christina Baechle, Brenda Bongaerts, Sabrina Schlesinger, Ferdinand Valentin Stoye, Oliver Kuss, Rüdiger Landgraf, Nafiseh Shokri‐Mashhadi, Anna‐Therese Klötzsch, Annika Hoyer, Wolfgang Rathmann
article en

Abstract

These results suggest that FPG is a more reliable diagnostic marker than HbA<sub>1c</sub> and that uniform global thresholds may not fully reflect population-specific differences. Further high-quality studies are needed to refine diagnostic performance and examine factors influencing accuracy.

Diabetes/Metabolism Research and ReviewsVol. 42(4)
Bielefeld University (DE), Deutsche Diabetes Stiftung (DE), Deutsches Diabetes-Zentrum e.V. (DE), German Center for Diabetes Research (DE), Heinrich Heine University Düsseldorf (DE)
Openalex Percentile: Top 6%
Diabetes, Cardiovascular Risks, and Lipoproteins
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