Clinical features of paraneoplastic neurologic syndromes with anti-Ri antibodies: PRISMA systematic review

Ri-PNS is a multisystem neurological syndrome with significant involvement of the cerebellum and brainstem. The syndrome is frequently associated with tumors, and its appearance often signals the presence of a concurrent or occult tumor. Anti-tumor therapy and immunotherapy remain the two major management approaches in treatment. Considering that early intervention has the potential to enhance neurological function and improve the prognosis in patients with Ri-PNS, it could be given particular attention in clinical practice.