Phenotypic alterations and PI3K-AKT pathway regulation in senescence of human tonsil mesenchymal stem cells
Our research proved that replicative senescence in TMSCs is associated with PI3K-Akt pathway activation, which likely orchestrates senescence via p16 and p53-p21 cascades. These findings provide new insights into the mechanisms of stem cell aging and suggest potential molecular targets for developing strategies to delay senescence in TMSCs for regenerative medicine.
Authors
- Anbang Zhao (ORCID: https://orcid.org/0000-0002-8608-4158)
- Yuechen Sun
- Xiaoyu Qiu
- Xiong Chen
- Zehua Lin
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1186/s13287-026-04986-7
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00