Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022

The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence-based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were decided based on the important clinical issues. For document retrieval, key words for literature searches were set for each CQ and literature published from 1980 to the end of December 2020 was searched in PubMed, and Japana Centra Revuo Medicina (JCRM). The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution Service (Minds) technique. A total of 38 CQs were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy, and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, pathological diagnosis deciding the diagnosis, and causal genes of vascular anomalies. Thus, the Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022 have been prepared as the evidence-based guidelines for the management of vascular anomalies.

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Publication Details

Journal
Surgery Today
Published
2026-03-27
DOI
https://doi.org/10.1007/s00595-025-03211-x
Primary Topic
Vascular Malformations and Hemangiomas
Type
article
Field-Weighted Citation Impact
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article

Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022

Kumiko Chuman, Masakazu Kurita, Shohei Takami, Hayato Maruguchi et al.
Surgery Today
Vascular Malformations and Hemangiomas
article

Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022

Kumiko Chuman, Masakazu Kurita, Shohei Takami, Hayato Maruguchi, Shinji Wada, Akihiro Fujino, Fumio Nagai, Kyoichi Deie, Takeshi Hirabayashi, Tamotsu Kobayashi, Norifumi Matsuda, Akira Higashiyama, Kiyokazu Kim, Kohji Yamamoto, Shuichi Tanoue, Sadanori Akita, Mizuki Uchiyama, Hiroki Yoshihara, Akiko Asai, Tomo Kakihara, Takanobu Maekawa, Kiichiro Yaguchi, Akifumi Nozawa, Keigo Osuga, Michio Ozeki, Yuki Iwashina, Yuta Nakajima, Tamihiro Kawakami, K. Tanaka, Shunsuke Yuzuriha, Sachiko Asayama, Shinsuke Takagi, Daisuke Maeda, Shiho Yasue, Hidehito Usui, Katsuyoshi Koh, Yasuyuki Yamahana, Eiichi Morii, Mayu Uka, Shien Seike, Junko Ochi, Kosuke Ishikawa, Asami Tozawa, Shinji Kagami, Naoya Oshima, Shunsuke Nosaka, Ami Kawaguchi, Nobuyuki Takakura, Naoaki Rikihisa, Yusuke Shikano, Rika Yoshimatsu, Naoki Murakami, Yohei Iwata, Masatoshi Jinnin, Akira Kitagawa, Masataka Takahashi, Takafumi Ohshiro, Akira Morimoto, Yasunari Niimi, Yoshiaki Kinoshita, Yuhki Arai, Mamoru Honda, Akiko Kishi, Shuichi Shimada, Aya Tanaka, Rintaro Ono, Keiji Suzuki, Ayato Hayashi, Kazuki Hashimoto, Masafumi Kamata, Reiko Takeda, Hiroki Nakaoka, Taro Kono, Takao Tachibana, Munezumi Fujita, Satoshi Hirakawa, Saori Endo, Michiko Nagahama, Mototoshi Kato, Takaya Fukumoto, Kenji Tsuboi, Miho Noguchi, Toshihiro Otsuka, Satoru Sasaki, Yuta Moriwaki, Taizo Furukawa, Yumiko Hori, Kentaro Matsuoka, Yoshihiro Kuwano, Naoki Hashizume, Noriko Aramaki-Hattori, Masashi Hayakawa, Takahide Kaneko, Hiroki Kanamori, Hideki Endo, Keiko Ogawa, Shiro Onozawa, Takeshi Saito, Hidefumi Mimura, Kuniaki Ohara, Hiroshi Furukawa, Mine Ozaki, Daichi Hayashi, Hiroshi Kitagawa, Ryo Nakatani, Masanori Inoue, Daisuke Hasegawa, Tadashi Nomura, Yasuhiro Nakamura, Yoko Aoki, Hideki Mori, Motoi Kato, Masashi Tamura, Ryohei Ishiura, Taiki Nozaki, Satoru Tamura, Kanako Danno
article en

Abstract

The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence-based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were decided based on the important clinical issues. For document retrieval, key words for literature searches were set for each CQ and literature published from 1980 to the end of December 2020 was searched in PubMed, and Japana Centra Revuo Medicina (JCRM). The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution Service (Minds) technique. A total of 38 CQs were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy, and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, pathological diagnosis deciding the diagnosis, and causal genes of vascular anomalies. Thus, the Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022 have been prepared as the evidence-based guidelines for the management of vascular anomalies.

Surgery Today
Kurume University (JP), Osaka Gakuin University (JP), Sapporo City University (JP), Toho University (JP), Fukushima Medical University (JP), Tokai University (JP), Hamamatsu University (JP), Yokkaichi University (JP), Shinshu University (JP), Fujita Health University (JP), Jichi Medical University (JP), St. Marianna University School of Medicine (JP), Aichi Medical University (JP), Kyoto Prefectural University (JP), Mie University (JP), Wakayama Medical University (JP), Kyorin University (JP), Unitika (Japan) (JP), Tohoku University (JP), Kagawa University (JP), Keio University (JP), Hokkaido University (JP), CHI Health (US), Hamamatsu University School of Medicine (JP), Osaka City University (JP), Kyoto Prefectural University of Medicine (JP), National Defense Medical College Hospital (JP), SKiN Health (CA), Kobe Medical Center (JP), St. Luke's International Hospital (JP), Toyonaka Municipal Hospital (JP), Matsuyama Shimin Hospital (JP), Kumamoto City Hospital (JP), Kochi Medical School Hospital (JP), Kobe University Hospital (JP), Osaka National Hospital (JP), Hoshigaoka Medical Center (JP), Saitama Children's Medical Center (JP), Ehime Medical Center (JP), Osaka City General Hospital (JP), Okayama University Hospital (JP), Japanese Red Cross Medical Center (JP), Tonan Hospital (JP), Suita Tokushukai Hospital (JP), Gifu University Hospital (JP), University of Tokyo Hospital (JP), Ehime University Hospital (JP), Osaka Rosai Hospital (JP), Nara City Hospital (JP), Kanagawa Children's Medical Center (JP), Mie University Hospital (JP), Nagoya Ekisaikai Hospital (JP), Kagoshima University Hospital (JP), Matsudo City Hospital (JP), Kagoshima City Hospital (JP), Kumamoto University Hospital (JP), Kanto Central Hospital (JP), Hiroshima University Hospital (JP), Ono Clinic (JP), National Center For Child Health and Development (JP), Saitama International Medical Center (JP), Saiseikai Matsuyama Hospital (JP), Chiba Hospital (JP), Tokyo Women's Medical University (JP), Juntendo University Urayasu Hospital (JP), Kyorin University Hospital (JP), Otsuka Pharmaceutical (Spain) (ES), Nagano Children's Hospital (JP), Tokyo Metropolitan Children's Medical Center (JP), Japanese Red Cross Society Kyoto Daini Hospital (JP), Okayama Medical Center (JP), Nippon Medical School Hospital (JP), SHOWA Medical University Fujigaoka Hospital (JP), Hokuto Hospital (JP), Tokushima Hospital (JP), Soma Central Hospital (JP), Kinan Hospital (JP), Hirosaki University Hospital (JP), Municipal Hirakata City Hospital (JP), Toranomon Hospital (JP), Gifu University (JP), National Defense Medical College (JP), Kobe University (JP), Niigata University (JP), The University of Tokyo (JP), Kōchi University (JP), Tohoku Medical and Pharmaceutical University (JP), Saitama Medical University (JP), Teikyo University (JP), Yokohama City University (JP), Osaka University of Pharmaceutical Sciences (JP), The University of Osaka (JP)
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