Integrating crystal engineering with PEG6000 conjugation to formulate advanced solid dispersions of febuxostat for gout management
The combined application of crystal engineering and PEG6000-based amorphous solid dispersions selectively enhances the solubility, dissolution, and in vitro biological performance of febuxostat. This strategy offers a rational approach for optimizing FEB formulations and addressing the limitations associated with poorly soluble drugs.
Authors
- Doriana T. Ungur (ORCID: https://orcid.org/0009-0001-9101-6571)
- Laura Pătraș (ORCID: https://orcid.org/0000-0002-6981-3881)
- Tudor Tămaş (ORCID: https://orcid.org/0000-0002-7032-5447)
- Coca Iordache
- Mihaela Maria Pop
- Alice Mija
- Manuela Banciu
Institutions
- Babeș-Bolyai University (RO)
- Institut de Chimie de Nice (FR)
- Research Institute for Analytical Instrumentation (RO)
- Institut de Physique de Nice (FR)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1093/jpp/rgag019
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00