Optimizing NT-proBNP Inclusion Cut-offs for Randomized Clinical Trials in Heart Failure: Data from the Swedish Heart Failure Registry
Higher NT-proBNP cut-offs were associated with increased event enrichment but also higher screening failure. These findings support the use of higher cut-offs currently used in HF RCTs and suggest that future trials should tailor NT-proBNP cut-offs to trial aims, balancing enrichment with enrolment feasibility and considering obesity and CKD in addition to EF and AF.
Authors
- Megan Schroeder (ORCID: https://orcid.org/0000-0003-4937-2887)
- Gianluigi Savarese (ORCID: https://orcid.org/0000-0001-7732-0887)
- Christoph Gerlinger (ORCID: https://orcid.org/0000-0003-4538-6413)
- Yvonne Mei Fong Lim (ORCID: https://orcid.org/0000-0002-3404-0153)
- Ulf Dahlström
- Stefan Koudstaal (ORCID: https://orcid.org/0000-0003-4982-6658)
- L H Lund
Institutions
- Linköping University (SE)
- Ministry of Health (MY)
- Karolinska University Hospital (SE)
- Zimmer Biomet (Netherlands) (NL)
- Utrecht University (NL)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- Stockholm South General Hospital (SE)
- Bayer (Germany) (DE)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
- Saarland University (DE)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1093/eschf/xvag089
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00