No association between troponin and COPD without cardiovascular influence: findings from a population-based cohort (SCAPIS)
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI -0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.
Authors
- Ola Hammarsten (ORCID: https://orcid.org/0000-0002-0772-6934)
- J Holm (ORCID: https://orcid.org/0000-0003-3443-3392)
- Åse A. Johnsson (ORCID: https://orcid.org/0000-0002-0352-5756)
- Hanan A. Tanash (ORCID: https://orcid.org/0000-0002-0913-2347)
- Ida Pesonen (ORCID: https://orcid.org/0000-0001-8977-7462)
- Emma Palmqvist
- Anders Lindén (ORCID: https://orcid.org/0000-0003-1258-2928)
- Per Liv (ORCID: https://orcid.org/0000-0002-5494-8134)
- Jonas Eriksson Ström (ORCID: https://orcid.org/0000-0002-3434-988X)
- Ulf J. Nilsson (ORCID: https://orcid.org/0000-0001-5815-9522)
- Jan Engvall (ORCID: https://orcid.org/0000-0002-5716-5098)
- Elin Solman Good
- Anna Moberg (ORCID: https://orcid.org/0000-0001-5431-8469)
- E Lindberg
- Anna-Lena Andersson
- Magnus Sköld
- Magnus Ekström
- Anders Blomberg
- Christer Janson
- Apostolos Bossios
- Josefin Sundh
- Suneela Zaigham
- Arne Egesten
- Lars Lind
- Andrei Malinovschi
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Lund University (SE)
- Örebro University (SE)
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Region Västra Götaland (SE)
- Skåne University Hospital (SE)
- Linköping University Hospital (SE)
- University of Gothenburg (SE)
- Umeå University (SE)
Publication Details
- Journal
- Thorax
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1136/thorax-2025-224120
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00