Diagnostic Timing and Ovarian Cancer Survival

In this cohort study of patients with OC, very short diagnostic intervals were associated with poorer survival, consistent with residual confounding by the wait time paradox, while longer diagnostic intervals were also associated with worse outcomes. Conventional linear approaches may obscure this important confounding by severity in the association between diagnostic timing and survival, contributing to null findings in prior studies and potentially discouraging efforts to improve diagnosis of this difficult-to-detect disease.