Acute Invasive Pulmonary Aspergillosis With <scp>CNS</scp> Dissemination in an Immunocompetent Individual: A Case Report

ABSTRACT Invasive pulmonary aspergillosis can occur in patients without classical immunosuppression, particularly those with COPD and corticosteroid exposure. Early recognition, prompt antifungal therapy, and vigilance for neurological symptoms are essential to prevent central nervous system dissemination, which carries high mortality and significant long‐term neurological morbidity despite aggressive treatment.

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Publication Details

Journal
Clinical Case Reports
Published
2026-03-27
DOI
https://doi.org/10.1002/ccr3.72387
Primary Topic
Antifungal resistance and susceptibility
Type
article
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article

Acute Invasive Pulmonary Aspergillosis With CNS Dissemination in an Immunocompetent Individual: A Case Report

Islam Rajab, Malina Mohtadi, Barbare Khatiashvili, Aqsa Zoey Sorathia et al.
Clinical Case Reports
Antifungal resistance and susceptibility
article

Acute Invasive Pulmonary Aspergillosis With CNS Dissemination in an Immunocompetent Individual: A Case Report

Islam Rajab, Malina Mohtadi, Barbare Khatiashvili, Aqsa Zoey Sorathia, Sarah Saife, Ghassan Makhoul, Ahmad Huzien, Shivanck Upadhyay, Arham Hazari
article en

Abstract

ABSTRACT Invasive pulmonary aspergillosis can occur in patients without classical immunosuppression, particularly those with COPD and corticosteroid exposure. Early recognition, prompt antifungal therapy, and vigilance for neurological symptoms are essential to prevent central nervous system dissemination, which carries high mortality and significant long‐term neurological morbidity despite aggressive treatment.

Clinical Case ReportsVol. 14(4)
An-Najah National University (PS), St. Joseph’s University Medical Center (US)
Good health and well-being
Openalex Percentile: Top 7%
Antifungal resistance and susceptibility
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