Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers
Bisulfite conversion has higher DNA methylation levels for certain CRC biomarkers in tumor tissues, suggesting over-estimation of methylation that could affect biomarker specificity.
Authors
- Kathryn Cornthwaite (ORCID: https://orcid.org/0000-0001-5484-3052)
- Ganessan Kichenadasse (ORCID: https://orcid.org/0000-0001-9923-5149)
- Stellene Vitaro
- Jean M Winter
- Erin L Symonds
- Geraldine Laven-Law
Institutions
- Flinders University (AU)
- Flinders Medical Centre (AU)
- Adelaide Institute for Sleep Health (AU)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1093/clinchem/hvag018
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00