IL-36G drives sepsis-induced lung injury via NF-κB-dependent activation of the NLRP3 inflammasome in macrophage pyroptosis
IL-36G promoted pyroptosis and NLRP3 inflammasome activation <i>via</i> NF-κB signaling pathway, contributing to sepsis-induced lung injury. Knockdown of IL-36G mitigated inflammation and tissue damage, indicating the therapeutic potential of IL-36G in sepsis.
Authors
- Mingguo Yan
- Z. Jeffrey Chen (ORCID: https://orcid.org/0000-0002-1520-3519)
- Yuan Song
- Zheng Yuan
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Experimental Lung Research
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1080/01902148.2026.2646045
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00