Upfront Radiation Therapy Increases Severe Neurotoxicity Risk in Patients With Oligodendrogliomas
Upfront RT was associated with a substantially higher rate of severe delayed toxicity, including radiation necrosis, stroke, and disabling dementia, without an apparent survival benefit. These findings support deferring RT until disease progression to reduce long-term treatment-related morbidity.
Authors
- Julia M. Martínez Gómez (ORCID: https://orcid.org/0000-0002-5684-3707)
- J. Li
- Michael Schulder (ORCID: https://orcid.org/0000-0003-1802-8223)
- Alexis Demopoulos
- JOHNATHAN KNISELY
- REEMA SHAH-DEMOPOULOS
Institutions
- Hartford Hospital (US)
- NewYork–Presbyterian Hospital (US)
- Cornell University (US)
- Presbyterian Hospital (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Barnard College (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-03-27
- DOI
- https://doi.org/10.21873/anticanres.18092
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00