<scp>Metallothionein</scp> Safeguards Hepatic Zn‐Fe Homeostasis and Restrains Yap‐Driven Hepatic Fe Overload to Protect Against Chronic Liver Fibrosis
These findings reveal MT as a key hepatocyte integrator of trace-metal homeostasis and Yap signalling and suggest that therapeutic strategies enhancing MT activity or combining Zn supplementation with Yap inhibition may offer new avenues to prevent or reverse chronic liver fibrosis.
Authors
- Yinrui Feng (ORCID: https://orcid.org/0000-0002-9637-9259)
- Yide Ma (ORCID: https://orcid.org/0000-0001-6098-7853)
- Zixuan Zhou (ORCID: https://orcid.org/0000-0002-6004-182X)
- Yundi Liu
- Dan Wang
- Ying Xiao
- Tao Wang
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Lanzhou University Second Hospital (CN)
- Tang Du Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Liver International
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1111/liv.70624
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00