A systems biology approach to identify common molecular signatures in Hashimoto's thyroiditis and rheumatoid arthritis
Our study findings suggest that the disruption of immune tolerance and aberrant immune activation are likely the primary mechanisms driving the comorbidity of HT and RA. The identified hub genes and their potential druggable targets provide a theoretical basis for subsequent experimental validation and the development of precision therapeutic strategies.
Authors
- Luping Lin (ORCID: https://orcid.org/0000-0002-5254-7193)
- Jian-bin Wei (ORCID: https://orcid.org/0009-0004-0972-5558)
- Qing-Ying Xu
- Yuan Lin
Institutions
- First Affiliated Hospital of Xiamen University (CN)
- Xiamen Chang Gung Hospital (CN)
- Putian University (CN)
Publication Details
- Journal
- The Aging Male
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1080/13685538.2026.2650005
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00