Global landscape of yttrium-90 clinical trials: a systematic registry-based analysis

Y-90 research has expanded globally, especially in liver cancer, but trials remain largely small, early phase, and geographically uneven, with limited dissemination. Strengthening methodological rigor through adequately powered multicenter trials, enhancing transparency in result dissemination, and encouraging broader research efforts in high-burden regions such as Asia may help further clarify the optimal role of Y-90 in oncology.