Menopausal hormone therapy in breast cancer survivors: A review

Highlights The use of menopausal hormone therapy by breast cancer survivors is controversial. Non-hormonal therapies are the first-line option but may not adequately control symptoms. Low-dose vaginal estrogen appears effective with minimal systemic absorption. The use of systemic menopausal hormone therapy remains debated due to heterogeneous and limited safety data. Management should be individualized, with multidisciplinary shared decision-making.

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Publication Details

Journal
Maturitas
Published
2026-03-01
DOI
https://doi.org/10.1016/j.maturitas.2026.108929
Primary Topic
Menopause: Health Impacts and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Menopausal hormone therapy in breast cancer survivors: A review

Holly J. Pederson, Lauren M. Granat, Megan Kruse
Maturitas
Menopause: Health Impacts and Treatments
article

Menopausal hormone therapy in breast cancer survivors: A review

Holly J. Pederson, Lauren M. Granat, Megan Kruse
article en

Abstract

Highlights The use of menopausal hormone therapy by breast cancer survivors is controversial. Non-hormonal therapies are the first-line option but may not adequately control symptoms. Low-dose vaginal estrogen appears effective with minimal systemic absorption. The use of systemic menopausal hormone therapy remains debated due to heterogeneous and limited safety data. Management should be individualized, with multidisciplinary shared decision-making.

Maturitas
Cleveland Clinic (US), Cleveland Clinic Lerner College of Medicine (US)
Good health and well-being
Openalex Percentile: Top 6%
Menopause: Health Impacts and Treatments
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