Phosphodiesterase 5 Inhibitor Sildenafil Inhibits HPV <sup>+</sup> Cervical Cancer Cells and Cervical Cancer Stem Cells by Apoptotic Induction and Telomerase Activity Modulation
The PDE5 inhibitor sildenafil might be repurposed to be a possible therapeutic option for treating cervical cancer. Its efficacy extends to both HPV-positivity and CSCs, addressing a significant portion of cervical cancer cases.
Authors
- Amrita Saha (ORCID: https://orcid.org/0000-0001-5377-4278)
- Ankan Biswas (ORCID: https://orcid.org/0000-0002-2085-2572)
- Debapratim Das (ORCID: https://orcid.org/0000-0003-2295-0966)
- Solanki Sarkar
- BASABKANTI DAS
Institutions
- Indian Institute of Technology Guwahati (IN)
- University of Kalyani (IN)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-03-27
- DOI
- https://doi.org/10.21873/anticanres.18090
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00