Discontinuation of RAS Inhibition After an Acute Decline in Estimated Glomerular Filtration Rate
This cohort study found that discontinuation of RASIs after an acute decline in eGFR was associated with ESKD and death compared with continuing RASIs. These findings suggest that further study is needed to understand reasons for frequent discontinuation of RASIs and devise strategies to improve their persistent use.
Authors
- Charles E. McCulloch (ORCID: https://orcid.org/0000-0002-1279-6179)
- Ranveer Brar (ORCID: https://orcid.org/0000-0001-6537-1505)
- Elaine Ku
- Navdeep Tangri
- Mark J. Sarnak
Institutions
- Tufts Medical Center (US)
- University of California, San Francisco (US)
- Seven Oaks General Hospital (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1001/jamanetworkopen.2026.3680
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00