Evaluation of novel treatments for metastatic castration-resistant prostate cancer

The therapeutic landscape of mCRPC has expanded substantially; however, treatment resistance and the absence of validated sequencing strategies continue to pose major challenges. Advancements in this field will rely on improved molecular profiling, biologically rational combination strategies, and the incorporation of predictive biomarkers to enable personalized treatment decisions. Concurrently, earlier integration of targeted therapies, radioligand approaches, and biomarker-enriched clinical trial designs is likely to reshape treatment paradigms and enhance long-term clinical outcomes.