Follicular Fluid Per- and Polyfluoroalkyl Substances (PFAS), Metabolomics and Live Birth Following IVF: A Pilot Study
Higher FF PFAS concentrations were associated with lower odds of achieving live birth, though most 95% confidence intervals included the null. Metabolic pathways enriched for features associated with live birth and features associated with FF PFAS were related to lipid, carbohydrate, vitamin, and cofactor metabolism. Although our sample size was small, our findings align with other studies characterizing environmental exposures in reproductive organs and using the metabolome to assess their impact on fertility.
Authors
- Allison F. Vitonis (ORCID: https://orcid.org/0000-0003-1243-0844)
- Emily Silva (ORCID: https://orcid.org/0000-0003-2251-6289)
- Anna S. Young (ORCID: https://orcid.org/0000-0002-6047-4406)
- Elvira S. Fleury (ORCID: https://orcid.org/0009-0009-6147-0683)
- Kathryn L. Terry (ORCID: https://orcid.org/0009-0002-5848-4661)
- Shruthi Mahalingaiah (ORCID: https://orcid.org/0000-0002-5527-5787)
- Elizabeth Peebles (ORCID: https://orcid.org/0009-0009-8814-5194)
- Daniel W. Cramer (ORCID: https://orcid.org/0000-0002-8024-3066)
- Zifan Wang (ORCID: https://orcid.org/0000-0001-6068-2902)
- C E Mullins
- Bo Rueda
- Douglas I. Walker
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Emory University (US)
Publication Details
- Journal
- F&S Science
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1016/j.xfss.2026.03.005
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00