Access to α-Alkynyl-α-fluoroacetamides via Deacylative Alkynylation of α-Fluoro-β-ketoamides with Alkynyliodonium Salts

A simple and efficient method for the synthesis of α-alkynyl-α-fluoroacetamides has been developed via alkynylation of α-fluoro-β-ketoamides using alkynyliodonium salts. Through a base-mediated alkynylation/deacylation cascade, this strategy offers direct access to fluorinated alkynylacetamides, a valuable class of compounds that remain synthetically challenging to prepare using conventional methods. The transformation demonstrates broad functional group tolerance, and the synthetic utility of these compounds was further demonstrated through their conversion into a diverse array of other key synthetic frameworks.