Improving lipid-lowering treatment and cardiovascular risk management in primary care: findings from an audit and feedback project
Introduction Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Low-density lipoprotein cholesterol (LDL-C) plays a central role in atherogenesis and cardiovascular events. In real-world primary care, many patients at high and very-high cardiovascular risk (HCVR) do not achieve recommended LDL-C targets. Objectives This study evaluated whether an audit and feedback (A&F) intervention could improve lipid management in HCVR patients managed in general practice. Methods We conducted a retrospective–prospective observational study involving general practitioners (GPs). GPs were classified as active, participating in A&F training and feedback sessions, or controls, contributing data only. Patient-level data were extracted from electronic medical records across three 18-month observation periods (T0, T1, and T2). Active GPs received tailored performance reports and educational sessions after T0 and T1. Main outcomes included completeness of clinical data recording, LDL-C target attainment (<70 mg/dL), lipid-lowering treatment patterns, and treatment adherence. Results Compared with baseline, active GPs showed significant improvements in the recording of LDL-C (+18.3%), HbA1c (+5.7%), body mass index (+17.1%), smoking status (+4.4%), and alcohol consumption (+14.4%). LDL-C target attainment increased from 6.1% at T0 to 14.5% at T2, exceeding the proportion observed in controls at T2 (8.7%). The use of lipid-lowering therapy among active GPs increased from 48.9% at T0 to 61.3% at T2, while high-intensity therapy increased from 9.1% to 17.6%. Treatment adherence improved over time, with a higher proportion of patients adherent to high-intensity therapy and a reduction in non-adherent low-intensity therapy. Conclusion An audit and feedback intervention supported by a multidisciplinary team improved data completeness and lipid management in high-risk patients in the primary care setting.
Authors
- Salvatore Corrao (ORCID: https://orcid.org/0000-0001-5621-1374)
- Sebastiano Marino
- Riccardo Scoglio
- Natasha Irrera (ORCID: https://orcid.org/0000-0002-1134-7080)
- Michelangelo Rottura (ORCID: https://orcid.org/0000-0001-5407-6535)
- Antonino Molonia (ORCID: https://orcid.org/0009-0004-2200-6793)
- Egidio Imbalzano (ORCID: https://orcid.org/0000-0003-2656-5467)
- Vincenzo Arcoraci (ORCID: https://orcid.org/0000-0003-0061-0477)
- Selene Francesca Anna Drago (ORCID: https://orcid.org/0000-0003-1469-6101)
- Giovanni Pallio (ORCID: https://orcid.org/0000-0002-4187-2265)
- G Mandraffino
- Viviana Maria Gianguzzo (ORCID: https://orcid.org/0009-0003-3855-2054)
- Federica Maria Sacco
Institutions
- University of Messina (IT)
- Società Italiana di Medicina Generale (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-27
- DOI
- https://doi.org/10.3389/fphar.2026.1787952
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00