Specific inhibition of p38α MAPK dampens neuroinflammation during acute alcohol withdrawal in mouse BV2 microglial cell line and rat organotypic hippocampal slice cultures

• Elevated CXCL1 during ethanol withdrawal in BV2 cells was abolished by MW150 • Increased TNFα during ethanol withdrawal in OHSCs was reduced by MW150 • MW150 may be effective in treating neuroinflammation during ethanol withdrawal

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Publication Details

Journal
Alcohol
Published
2026-03-01
DOI
https://doi.org/10.1016/j.alcohol.2026.03.007
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Specific inhibition of p38α MAPK dampens neuroinflammation during acute alcohol withdrawal in mouse BV2 microglial cell line and rat organotypic hippocampal slice cultures

C.S. Bailey, LJ Van Eldik, D.J. Braun, M.C. Green et al.
Alcohol
Neuroinflammation and Neurodegeneration Mechanisms
article

Specific inhibition of p38α MAPK dampens neuroinflammation during acute alcohol withdrawal in mouse BV2 microglial cell line and rat organotypic hippocampal slice cultures

C.S. Bailey, LJ Van Eldik, D.J. Braun, M.C. Green, C.T. Leibold
article en

Abstract

• Elevated CXCL1 during ethanol withdrawal in BV2 cells was abolished by MW150 • Increased TNFα during ethanol withdrawal in OHSCs was reduced by MW150 • MW150 may be effective in treating neuroinflammation during ethanol withdrawal

Alcohol
University of Kentucky (US)
Good health and well-being
Openalex Percentile: Top 24%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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Specific inhibition of p38α MAPK dampens neuroinflammation during acute alcohol withdrawal in mouse BV2 microglial cell line and rat organotypic hippocampal slice cultures — C.S. Bailey, LJ Van Eldik, et al. · Alcohol (2026) | TGRS Research Map | TGRS