Trivalent multi-epitope mRNA vaccine against norovirus, rotavirus, and adenovirus 40/41: epitope screening, molecular docking, and molecular dynamics simulation with in silico validation guided by immunoinformatics
The computationally designed vaccine in this study was predicted to exhibit favorable structural stability, potential immune activation capability, and promising broad population coverage, providing preliminary insights for the development of vaccines against multiple viral co-infections; however, its immunogenicity and safety remain to be further validated through animal model experiments.
Authors
- Yuying Luo (ORCID: https://orcid.org/0000-0003-1738-0313)
- Y. R. Hou (ORCID: https://orcid.org/0000-0001-6454-278X)
- Jie Chen (ORCID: https://orcid.org/0000-0002-5929-7262)
- Yizhong Xu
- Rongliu Qin
- Pan P
- Ziyou Zhou
- Ruping Qu
- Fei Zhu
- Xu Wu
- Shiyang Ma
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Hunan University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Hunan Mawangdui Hospital (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1186/s40249-026-01431-y
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00