Locoregional delivery of CAR T cells in high-grade gliomas: a systematic analysis of safety, efficacy, and emerging biomarkers of response
Intracranial delivery of CAR-T cells helps overcome key barriers that limit the efficacy and safety of systemic therapy in brain tumors. These findings support a paradigm shift that integrates locoregional delivery techniques as a pivotal component in the design of future CAR-T cell trials, offering a safer and potentially more effective therapeutic approach with greater opportunities for longitudinal sampling for patients with HGG.
Authors
- Dagoberto Estévez-Ordoñez (ORCID: https://orcid.org/0000-0002-8876-1044)
- Daniel Kreatsoulas (ORCID: https://orcid.org/0000-0002-9727-7019)
- Ankit Shah (ORCID: https://orcid.org/0000-0002-6701-3258)
- Vratko Himič (ORCID: https://orcid.org/0000-0002-3906-5317)
- Vaidya Govindarajan (ORCID: https://orcid.org/0000-0002-0248-346X)
- Jay Chandar (ORCID: https://orcid.org/0000-0001-5923-3579)
- Manav Daftari (ORCID: https://orcid.org/0009-0002-4206-6262)
- Anurag Aka
- Manuela Maria Aramburu-Berckemeyer
- Michael E Ivan
- Christian K Ramsoomair
- Ricardo J Komotar
- Rami Benchouia
Institutions
- University of Miami (US)
- University of Miami Hospital (US)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1136/jitc-2025-014450
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00