Septoria tritici blotch resistance gene Stb15 encodes a lectin receptor-like kinase
Septoria tritici blotch (STB), caused by the Dothideomycete fungus Zymoseptoria tritici, is one of the most damaging diseases of bread wheat (Triticum aestivum)$^{1}$ and the target of costly fungicide applications$^{2}$. In line with the fungus’s apoplastic lifestyle, STB resistance genes isolated to date encode receptor-like kinases (RLKs) including a wall-associated kinase (Stb6) and a cysteine-rich kinase (Stb16q)$^{3,4}$. Here we used genome-wide association studies on a diverse panel of 300 whole-genome shotgun-sequenced wheat landraces (WatSeq consortium$^{5}$) to identify a 99-kb region containing six candidates for the Stb15 resistance gene. Mutagenesis and transgenesis confirmed a gene encoding an intronless G-type lectin RLK as Stb15. The characterization of Stb15 exemplifies the unexpected diversity of RLKs conferring Z. tritici resistance in wheat.
Authors
- Luzie U. Wingen (ORCID: https://orcid.org/0000-0002-4682-4764)
- Amber N. Hafeez (ORCID: https://orcid.org/0000-0003-4692-5001)
- Mei Jiang (ORCID: https://orcid.org/0009-0006-2751-7124)
- Laëtitia Chartrain
- Mark A. Smedley (ORCID: https://orcid.org/0000-0002-6162-4795)
- Oliver R. Powell (ORCID: https://orcid.org/0000-0001-5624-8126)
- Florence Cambon
- Martha Clarke
- Cyrille Saintenac (ORCID: https://orcid.org/0000-0002-3791-301X)
- James K. M. Brown (ORCID: https://orcid.org/0000-0001-8719-2268)
- Cong Feng (ORCID: https://orcid.org/0009-0004-5453-6879)
- Rachel Kirby
- Simon Griffiths
- Markus C. Kolodziej
- Shifeng Cheng
- Brande B. H. Wulff
- Beat Keller
- Sadiye Hayta
- Burkhard Steuernagel
- Wenfei Xian
Publication Details
- Journal
- Universität Zürich, ZORA
- Published
- 2025-03-14
- DOI
- https://doi.org/10.5167/uzh-433455
- Primary Topic
- Wheat and Barley Genetics and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00