Addressing degeneracy in rodent studies of cognition

In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that actually use those computations, as opposed to simpler heuristics. Here, I describe the problem of adjudicating between degenerate behavioral algorithms and degenerate neural implementations in perceptual and value-based decision-making tasks. Multi-dimensional behavioral measures allow researchers to build arguments from numerous lines of evidence in favor of or against hypotheses about algorithmic strategies. Neural perturbations and individual differences can help resolve degenerate neural implementations. Rigorously contending with these issues is critical for leveraging rodent models to reveal mechanisms of cognition.

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Publication Details

Journal
Current Opinion in Neurobiology
Published
2026-03-27
DOI
https://doi.org/10.1016/j.conb.2026.103190
Primary Topic
Neural dynamics and brain function
Type
article
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article

Addressing degeneracy in rodent studies of cognition

Christine M. Constantinople
Current Opinion in Neurobiology
Neural dynamics and brain function
article

Addressing degeneracy in rodent studies of cognition

Christine M. Constantinople
article en

Abstract

In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that actually use those computations, as opposed to simpler heuristics. Here, I describe the problem of adjudicating between degenerate behavioral algorithms and degenerate neural implementations in perceptual and value-based decision-making tasks. Multi-dimensional behavioral measures allow researchers to build arguments from numerous lines of evidence in favor of or against hypotheses about algorithmic strategies. Neural perturbations and individual differences can help resolve degenerate neural implementations. Rigorously contending with these issues is critical for leveraging rodent models to reveal mechanisms of cognition.

Current Opinion in NeurobiologyVol. 98
New York University (US)
Peace, Justice and strong institutions
Openalex Percentile: Top 10%
Neural dynamics and brain function
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