VEGF and Hypoxia Independently Induce MDR1 Expression to Promote Endothelial Cell Angiogenesis
VEGF and hypoxia independently induce MDR1 expression in endothelial cells through distinct signaling pathways. MDR1 functions as a key mediator of angiogenesis independent of its classical drug efflux role, highlighting its potential as a therapeutic target in angiogenesis-related vascular diseases.
Authors
- Pil‐Young Yun (ORCID: https://orcid.org/0000-0001-6097-1229)
- Sung‐Gook Cho (ORCID: https://orcid.org/0000-0002-8791-9532)
- Min Kyoung Kim
- Hyeong Sim Choi
- SEONG-GYU KO
Institutions
- Korea National University of Transportation (KR)
- Seoul National University (KR)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-03-27
- DOI
- https://doi.org/10.21873/anticanres.18083
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00