BIT1 as an Effector of EGFR-TKI-induced Apoptosis <i>via</i> TLE1 Inhibition in Lung Adenocarcinoma Cells
The Bit1/TLE1 axis is a pivotal regulatory switch dictating apoptotic outcomes following EGFR-TKI treatment. This mechanism identifies a therapeutic vulnerability, suggesting that pharmacological Bit1 pathway activation could be an effective strategy to overcome acquired resistance in LUAD.
Authors
- Xin Yao (ORCID: https://orcid.org/0000-0002-9447-2003)
- Hector Biliran (ORCID: https://orcid.org/0000-0001-5711-0532)
- Renwei Chen (ORCID: https://orcid.org/0000-0002-1322-5378)
- James Bailey (ORCID: https://orcid.org/0000-0002-3769-3811)
- Ma. Carmela Dela Cruz
- Alajah Nealy
- PAUL MARK MEDINA
- MICAH NALLS
Institutions
- University of California, Santa Barbara (US)
- Xavier University of Louisiana (US)
- University of the Philippines Manila (PH)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-03-27
- DOI
- https://doi.org/10.21873/anticanres.18075
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00