Comparison of Infectious Complications After Transrectal Prostate Biopsy Under Two Antibiotic Prophylaxis Regimens: Ceftriaxone Plus Cefixime Versus Ciprofloxacin Plus Gentamicin

The combination of ceftriaxone and cefixime showed a safety profile broadly consistent with the combination of ciprofloxacin and gentamicin for biopsy prophylaxis. Considering increasing fluoroquinolone resistance and growing restrictions, this cephalosporin-based regimen may be considered a feasible option for transrectal ultrasound-guided prostate biopsy when implemented together with strict antiseptic measures.