Liver-directed AAV-IL-10 therapy enhances CD8 <sup>+</sup> T cell-mediated immunity against hepatocellular carcinoma
Liver-directed AAV-IL-10 delivery overcomes local immunosuppression and enhances CD8<sup>+</sup> T cell-mediated antitumor immunity in murine HCC models. These findings support targeted IL-10 delivery as a promising strategy to improve immunotherapy outcomes in liver cancer.
Authors
- Ya-Hui Chuang
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Y-Y Wu
- Chia-I. Lin
- Yi-Wei Chiu
- Meng-Syuan Yen
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1136/jitc-2025-012460
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00