Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells
SM-23 enhances MEK/ERK pathway inhibition through improved kinase binding affinity and demonstrates potent antiproliferative activity in colorectal cancer cells. These findings identify SM-23 as a promising MEK/ERK-targeted candidate for further therapeutic development.
Authors
- Pithi Chanvorachote (ORCID: https://orcid.org/0000-0002-3103-3249)
- Zin Zin (ORCID: https://orcid.org/0000-0001-7906-0986)
- Masashi Yokoya (ORCID: https://orcid.org/0000-0003-0187-7595)
- Preedakorn Chunhacha (ORCID: https://orcid.org/0000-0002-5060-7113)
- Satapat Racha
- RIKAKO YAMASHITA
- PATTHARAPORN SAELIM
Institutions
- Chulalongkorn University (TH)
- Meiji Pharmaceutical University (JP)
- Silpakorn University (TH)
Publication Details
- Journal
- Anticancer Research
- Published
- 2026-03-27
- DOI
- https://doi.org/10.21873/anticanres.18087
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00