Effect of Metformin Treatment on Gonadotropin Levels in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis of 51 Randomised Controlled Trials

Our meta-analysis, the largest one conducted to date, indicates that metformin does not significantly affect circulating gonadotropin levels in reproductive-age women with PCOS.

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Publication Details

Journal
Diabetes Obesity and Metabolism
Published
2026-03-27
DOI
https://doi.org/10.1111/dom.70719
Primary Topic
Ovarian function and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Effect of Metformin Treatment on Gonadotropin Levels in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis of 51 Randomised Controlled Trials

R. Krysiak, Mario Simental‐Mendía, Luis E. Simental‐Mendía
Diabetes Obesity and Metabolism
Ovarian function and disorders
article

Effect of Metformin Treatment on Gonadotropin Levels in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis of 51 Randomised Controlled Trials

R. Krysiak, Mario Simental‐Mendía, Luis E. Simental‐Mendía
article en

Abstract

Our meta-analysis, the largest one conducted to date, indicates that metformin does not significantly affect circulating gonadotropin levels in reproductive-age women with PCOS.

Diabetes Obesity and Metabolism
Mexican Social Security Institute (MX), Medical University of Silesia (PL), Universidad Autónoma de Nuevo León (MX), Durango Institute of Technology (MX), Hospital Universitario Dr José Eleuterio Gonzalez (MX)
Openalex Percentile: Top 5%
Ovarian function and disorders
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