Emergence of Plasmodium falciparum pfdhps A581G mutation in Southern Senegal under Seasonal Malaria Chemoprevention pressure, 2020-2023
After a decade of seasonal chemoprevention, P. falciparum in southern Senegal carries multiple genetic markers associated with resistance to sulfadoxine-pyrimethamine, including a recent increase in the pfdhps A581G mutation to over 10 %. Although the sulfadoxine-pyrimethamine plus amodiaquine regimen remains clinically effective, the growing frequency of pfdhps A581G mutation warrants close monitoring.
Authors
- Khadim Diongue (ORCID: https://orcid.org/0000-0002-7033-1169)
- Mamane Nassirou Garba (ORCID: https://orcid.org/0000-0003-1277-7696)
- Yaye Ndiaye
- Ibrahima Mbaye Ndiaye (ORCID: https://orcid.org/0000-0003-1049-8263)
- Jules François Gomis (ORCID: https://orcid.org/0000-0002-5961-570X)
- Abdoulaye Tine (ORCID: https://orcid.org/0000-0002-3500-1703)
- Mame Cheikh Seck (ORCID: https://orcid.org/0000-0002-8326-5359)
- Amy Gaye (ORCID: https://orcid.org/0000-0001-6604-8005)
- Awa Bineta Deme
- Aida Sadikh Badiane
- Daouda Ndiaye
- Bassirou Ngom
- Aita Sene
- Djiby Sow
- Mamadou S. Yade
- Mamadou Alpha Diallo
- Mouhamadou Ndiaye
- Baba Dieye
Institutions
- Cheikh Anta Diop University (SN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-27
- DOI
- https://doi.org/10.1038/s43856-026-01553-2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00