Bisphenol A exposure impairs cardiometabolic health: Integrative human evidence and zebrafish heart multi-omics analysis

BPA exposure is associated with elevated CMI in humans, with partial mediation by systemic inflammation. In zebrafish, BPA directly induces cardiac transcriptional and metabolic reprogramming, particularly affecting lipid and steroid pathways. These findings provide mechanistic insights into the link between BPA and cardiometabolic risk.