Organophotocatalytic Synthesis of Polycyclic Sultones and Sultams with FSO <sub>2</sub> Cl through Fluorosulfonyl Radical Cation Synthon Strategy
An organophotocatalytic strategy for constructing polycyclic sultones and sultams has been developed. Utilizing sulfuryl chloride fluoride (FSO<sub>2</sub>Cl) as a SO<sub>2</sub> radical cation synthon, a wide range of sultones and sultams were efficiently constructed from readily available propargyl alcohols and amines under mild conditions. This cascade transformation proceeds via radical fluorosulfonylation of alkynes, followed by radical <i>ortho</i>-cyclization and an intramolecular sulfur(VI) fluoride exchange (SuFEx) process.
Authors
- Yanju Lu (ORCID: https://orcid.org/0000-0002-1914-1204)
- Shenlin Huang (ORCID: https://orcid.org/0009-0003-4005-963X)
- Haoyuan Cheng
- Tianyu He
- Yukai Liu
- Yan Zhao
Institutions
- Yunnan Normal University (CN)
- Nanjing Forestry University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c00689
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00