IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8 <sup>+</sup> T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression
Combined IL-15 and Tα1 therapy reverses CD8<sup>+</sup> T cell senescence and enhances antitumor immunity in HCC through suppression of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway.
Authors
- Jia Xu (ORCID: https://orcid.org/0000-0002-1091-8558)
- Yao Chen (ORCID: https://orcid.org/0000-0001-7231-9860)
- Zixuan Guo
- Zhi Chen
- Jun Guan
- Fengtian Wu
Institutions
- National Centre for Infectious Diseases (SG)
- South China Institute of Collaborative Innovation (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1111/jgh.70359
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00