The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney
This study demonstrates that gestational low-protein diet reduces nephron endowment by impairing nephron progenitor cell commitment, with concurrent alterations in branching morphogenesis. These findings position disrupted progenitor commitment as a central developmental mechanism underlying nephron deficit in this model.
Authors
- Andrew Keniry (ORCID: https://orcid.org/0000-0002-4061-9540)
- Ian Smyth (ORCID: https://orcid.org/0000-0002-1727-7829)
- Lynelle K. Jones
- Francesca Edgington-Giordano
- Giovane G. Tortelote (ORCID: https://orcid.org/0000-0002-9312-3442)
- Marnie E. Blewitt (ORCID: https://orcid.org/0000-0002-2984-1474)
- Fabiola Diniz (ORCID: https://orcid.org/0000-0003-3302-0510)
- Kieran M. Short (ORCID: https://orcid.org/0000-0001-9137-008X)
- Jan Schröder (ORCID: https://orcid.org/0000-0001-5270-0605)
- Ashley Spencer
- Luise A. Cullen-McEwen
- Jose M. Polo
- Samir S. El-Dahr
- John F. Bertram
Institutions
- Tulane University (US)
- The University of Melbourne (AU)
- Parks Victoria (AU)
- Discovery Institute (US)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1681/asn.0000001053
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00