Circulating Nucleosomes Are Elevated In Trauma Patients With Venous Thromboembolism: A Prospective Case-Cohort Study

Levels of the H3.1 and H3R8 Cit nucleosomes are elevated early after traumatic injury, especially in those who developed VTE. These findings underscore the importance of understanding the pathophysiology of nucleosomes in inducing VTE and their role as biomarkers.Study Type: Prospective study with less than large effect and no negative criteria.Level of Evidence: II.

Authors

Sergio M. Navarro (ORCID: https://orcid.org/0000-0003-3455-1567)
Riley J. Thompson
Rosemary A. Kozar (ORCID: https://orcid.org/0000-0002-9582-8622)
Dong Chen (ORCID: https://orcid.org/0000-0001-7627-9560)
Grant M. Spears
Myung S. Park
Christina Wheeler
Jing-Fei Dong
Kent R. Bailey
Theresa K. Kelly

Institutions

University of Maryland, Baltimore (US)
University of Minnesota (US)
University of Maryland Medical Center (US)
Mayo Clinic (US)
Bloodworks Northwest (US)
Henderson Community College (US)
Twin Cities Orthopedics (US)
Mayo Clinic in Florida (US)

Publication Details

Journal: Shock
Published: 2026-03-16
DOI: https://doi.org/10.1097/shk.0000000000002807
Primary Topic: Acute Myeloid Leukemia Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Circulating Nucleosomes Are Elevated In Trauma Patients With Venous Thromboembolism: A Prospective Case-Cohort Study

Sergio M. Navarro, Riley J. Thompson, Rosemary A. Kozar, Dong Chen et al.

Mar 16, 2026

Shock

Acute Myeloid Leukemia Research

article

Circulating Nucleosomes Are Elevated In Trauma Patients With Venous Thromboembolism: A Prospective Case-Cohort Study

Sergio M. Navarro, Riley J. Thompson, Rosemary A. Kozar, Dong Chen, Grant M. Spears, Myung S. Park, Christina Wheeler, Jing-Fei Dong, Kent R. Bailey, Theresa K. Kelly

March 16, 2026article en

Abstract

Levels of the H3.1 and H3R8 Cit nucleosomes are elevated early after traumatic injury, especially in those who developed VTE. These findings underscore the importance of understanding the pathophysiology of nucleosomes in inducing VTE and their role as biomarkers.Study Type: Prospective study with less than large effect and no negative criteria.Level of Evidence: II.

Shock

University of Maryland, Baltimore (US), University of Minnesota (US), University of Maryland Medical Center (US), Mayo Clinic (US), Bloodworks Northwest (US), Henderson Community College (US), Twin Cities Orthopedics (US), Mayo Clinic in Florida (US)

Reduced inequalities

Openalex Percentile: Top 5%

Acute Myeloid Leukemia Research

DOI Source OpenAlex

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Circulating Nucleosomes Are Elevated In Trauma Patients With Venous Thromboembolism: A Prospective Case-Cohort Study — Sergio M. Navarro, Riley J. Thompson, et al. · Shock (2026) | TGRS Research Map | TGRS