Potassium binders and continuation of renin–angiotensin system inhibitors/mineralocorticoid receptor antagonist in chronic kidney disease and heart failure (the DEMONSTRATE database)
Second-generation potassium binders were associated with higher RAASi persistence than first-generation binders. RASi persistence was associated with lower observed rates of all-cause mortality and hospitalization, with no clear differences in 3P-MACE. These findings suggest that potassium binders may enable sustained RAASi use in patients with ND-CKD and/or HF.
Authors
- Maria K Eriksson Svensson (ORCID: https://orcid.org/0000-0001-7545-5585)
- Matilda Almstedt (ORCID: https://orcid.org/0009-0001-7160-3285)
- Hans Furuland (ORCID: https://orcid.org/0000-0002-9001-614X)
- Thomas Cars (ORCID: https://orcid.org/0009-0008-0912-8226)
- Milica Uhde
- Kristel Parv (ORCID: https://orcid.org/0000-0002-1238-9338)
- A Larsson
Institutions
- Uppsala University Hospital (SE)
- Pharma Nord (United Kingdom) (GB)
- Olink Bioscience (Sweden) (SE)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1111/joim.70087
- Primary Topic
- Potassium and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00