Knockdown of EFEMP1 Promotes Ferroptosis by Inactivating PI3K/AKT to overcome the Resistance of Hepatocellular Carcinoma Cells to Sorafenib

Knockdown of EFEMP1 promotes ferroptosis by inactivating PI3K/AKT to resensitize sorafenib-resistant HCC cells to sorafenib.

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Publication Details

Journal
Journal of Gastrointestinal and Liver Diseases
Published
2026-03-26
DOI
https://doi.org/10.15403/jgld-6499
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Knockdown of EFEMP1 Promotes Ferroptosis by Inactivating PI3K/AKT to overcome the Resistance of Hepatocellular Carcinoma Cells to Sorafenib

Ti Zhou, Yao Ma, Haibin Lan, Donglin Fang
Journal of Gastrointestinal and Liver Diseases
Ferroptosis and cancer prognosis
article

Knockdown of EFEMP1 Promotes Ferroptosis by Inactivating PI3K/AKT to overcome the Resistance of Hepatocellular Carcinoma Cells to Sorafenib

Ti Zhou, Yao Ma, Haibin Lan, Donglin Fang
article en

Abstract

Knockdown of EFEMP1 promotes ferroptosis by inactivating PI3K/AKT to resensitize sorafenib-resistant HCC cells to sorafenib.

Journal of Gastrointestinal and Liver DiseasesVol. 35(1)
Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Good health and well-being
Openalex Percentile: Top 6%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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Knockdown of EFEMP1 Promotes Ferroptosis by Inactivating PI3K/AKT to overcome the Resistance of Hepatocellular Carcinoma Cells to Sorafenib — Ti Zhou, Yao Ma, et al. · Journal of Gastrointestinal and Liver Diseases (2026) | TGRS Research Map | TGRS