Role of Provocation and Exercise Imaging for the Identification of Candidates for Cardiac Myosin Inhibitors
Patients requiring exercise echocardiography to document qualifying LVOTO do not exhibit a milder disease phenotype and derive similar treatment benefits from mavacamten compared to those with resting or Valsalva-provoked obstruction. Exercise echocardiography identifies a substantial proportion of symptomatic HCM patients with significant LVOTO missed by resting assessment and is essential for guiding treatment eligibility.
Authors
- Marnicq Van Es
- Philippe B. Bertrand (ORCID: https://orcid.org/0000-0001-6324-6874)
- Sebastiaan Dhont (ORCID: https://orcid.org/0000-0002-5615-3191)
- Wilfried Müllens (ORCID: https://orcid.org/0000-0001-9995-8590)
- Jonas Erzeel
- Duhan Ulgar
- Pieter Martens
Institutions
- Ziekenhuis Oost-Limburg (BE)
- Hasselt University (BE)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1093/eschf/xvag087
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00