Identifying Priority Outcomes for Mothers and Babies in Pregnancies With Preterm Pre‐Labour Rupture of Membranes for Future Clinical Trials

Preterm pre-labour rupture of membranes (PPROM) is associated with neonatal and maternal morbidity and mortality. Maternal prophylactic antibiotic therapy after PPROM improves outcomes but there is limited evidence to guide the optimal antibiotic regimen. This study surveyed 45 women with PPROM to understand consumer priorities for care, maternal and neonatal outcomes; and inform future PPROM clinical trial design. The highest priorities were prolonging gestation, avoiding brain injury, improving neonatal survival and good childhood respiratory health. Seventy-nine percent of respondents would consider clinical trial participation. Identifying consumer priorities will support both trial design and improved clinical care.