Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review

Tetracyclines may provide therapeutic options for refractory or MDR-related BJIs, and for suppressive therapy when surgical or antibiotic alternatives are limited. However, available data are heterogeneous and largely observational. Robust prospective studies are needed to clarify their role, particularly for newer agents such as omadacycline and eravacycline.

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Publication Details

Journal
Infectious Diseases and Therapy
Published
2026-03-26
DOI
https://doi.org/10.1007/s40121-026-01324-5
Primary Topic
Orthopedic Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review

J. Lavigne, Albert Sotto, Agathe Artiaga, Paul Laffont-Lozes et al.
Infectious Diseases and Therapy
Orthopedic Infections and Treatments
article

Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review

J. Lavigne, Albert Sotto, Agathe Artiaga, Paul Laffont-Lozes, Paul Loubet, Romaric Larcher
article en

Abstract

Tetracyclines may provide therapeutic options for refractory or MDR-related BJIs, and for suppressive therapy when surgical or antibiotic alternatives are limited. However, available data are heterogeneous and largely observational. Robust prospective studies are needed to clarify their role, particularly for newer agents such as omadacycline and eravacycline.

Infectious Diseases and Therapy
Centre National de la Recherche Scientifique (FR), Inserm (FR), Université de Montpellier (FR), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Centre Hospitalier Universitaire de Montpellier (FR), Centre Hospitalier Universitaire de Nîmes (FR), Université de Nîmes (FR)
Good health and well-being
Openalex Percentile: Top 6%
Orthopedic Infections and Treatments
DOIOpen Access PDFOpenAlex
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