Toxicity of Capecitabine and Oxaliplatin as Adjuvant Therapy for Stage III Colorectal Cancer Patients With Diverting Stoma

Patients with a diverting stoma who receive adjuvant chemotherapy with fluoropyrimidines and oxaliplatin are at higher risk of severe digestive toxicities when treated with the CAPOX regimen. The mFOLFOX6 regimen appears to be safer alternative in this population.

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Publication Details

Journal
JCO Oncology Practice
Published
2026-03-26
DOI
https://doi.org/10.1200/op-25-01035
Primary Topic
Colorectal Cancer Surgical Treatments
Type
article
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article

Toxicity of Capecitabine and Oxaliplatin as Adjuvant Therapy for Stage III Colorectal Cancer Patients With Diverting Stoma

A Marqués, Thibault Voron, D. Vernerey, Julie Henriques et al.
JCO Oncology Practice
Colorectal Cancer Surgical Treatments
article

Toxicity of Capecitabine and Oxaliplatin as Adjuvant Therapy for Stage III Colorectal Cancer Patients With Diverting Stoma

A Marqués, Thibault Voron, D. Vernerey, Julie Henriques, T. Samaille, Y. Parc, Thierry André, Jérémie H. Lefevre, Romain Cohen
article en

Abstract

Patients with a diverting stoma who receive adjuvant chemotherapy with fluoropyrimidines and oxaliplatin are at higher risk of severe digestive toxicities when treated with the CAPOX regimen. The mFOLFOX6 regimen appears to be safer alternative in this population.

JCO Oncology Practice
Inserm (FR), Sorbonne Université (FR), Methodology and Quality of Life Unit in Oncology (FR), La Ligue Contre le Cancer (FR), Assistance Publique – Hôpitaux de Paris (FR), Hôpital Saint-Antoine (FR), Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR), Centre de Recherche Saint-Antoine (FR), Université de Franche-Comté (FR)
Good health and well-being
Openalex Percentile: Top 7%
Colorectal Cancer Surgical Treatments
DOISourceOpenAlex
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Toxicity of Capecitabine and Oxaliplatin as Adjuvant Therapy for Stage III Colorectal Cancer Patients With Diverting Stoma — A Marqués, Thibault Voron, et al. · JCO Oncology Practice (2026) | TGRS Research Map | TGRS